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New publication: How sugar drives the virulence of rice pathogens

In a recently published study resulting from a collaboration between the laboratories of Bing Yang and Wolf Frommer, with Nora Zöllner as first author, our team investigated the role of sucrose in the virulence of the rice pathogen Xanthomonas oryzae pv. oryzae, the causative agent of bacterial leaf blight.

The study shows that the pathogen actively takes up and utilizes plant sucrose released from host cells via SWEET transporters. The authors identified a specific gene cluster, the so-called sux locus, which is responsible for the transport and degradation of sucrose. In particular, the sucrose symporter SuxC and the sucrose hydrolase SuxB are crucial for bacterial growth, fitness, and full virulence on different rice varieties. The study proves that sucrose not only serves as a nutrient, but also promotes bacterial motility, biofilm formation, the production of extracellular polysaccharides, and colonization of the xylem. The publication thus provides important new insights into the molecular mechanisms of pathogenicity and opens up avenues for innovative strategies for plant protection (link to publication).